AI-designed DNA switches

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 Scientists from Jackson Laboratory, MIT's Broad Institute, and Yale have created artificial intelligence (AI)-designed DNA switches that can precisely turn genes on or off in particular cell types, such as blood, liver, or brain cells, without affecting other organs. With this method, artificial DNA sequences known as cis-regulatory elements (CREs) that exclusively activate genes in specific tissues are created using machine learning. This discovery may open the door to targeted therapies, which would provide researchers and medical professionals exact control over gene expression for research and therapy, potentially revolutionising the use of genetic medicine in the future. In order to regulate gene activity in certain cell types, including the brain, liver, or blood, the Yale, MIT Broad Institute, and Jackson Laboratory research team has used artificial intelligence (AI) to design thousands of distinct DNA switches. These artificially generated cis-regulatory components

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